The association between interpregnancy interval and birth weight: what is the role of maternal polyunsaturated fatty acid status?
BMC Pregnancy Childbirth
; 13: 23, 2013 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-23351191
ABSTRACT
BACKGROUND:
The objective of this study was to evaluate the mediating role of maternal early pregnancy plasma levels of long chain polyunsaturated fatty acids (LCPUFAs) in the association of interpregnancy interval (IPI) with birth weight and smallness for gestational age (SGA) at birth.METHODS:
We analysed a subsample of the Amsterdam Born Children and their Development (ABCD) cohort, comprising 1,659 parous pregnant women recruited between January 2003 and March 2004. We used linear and logistic regression to evaluate the associations between fatty acid status, interpregnancy interval and pregnancy outcome.RESULTS:
Low plasma phospholipids concentrations of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and dihomo-gamma-linolenic acid (DGLA), and high concentrations of arachidonic acid (AA) during early pregnancy were associated with reduced birth weight and/or an increased risk of SGA. Short IPIs (< 6 months, with 18-23 months as a reference) were associated with a mean decrease of 207.6 g (SE ± 73.1) in birth weight (p = 0.005) and a twofold increased risk of SGA (OR 2.05; CI 0.93-4.51; p = 0.074). Adjustment for maternal fatty acid concentrations did not affect these results to any meaningful extent.CONCLUSIONS:
Despite the observed association of maternal early pregnancy LCPUFA status with birth weight and SGA, our study provides no evidence for the existence of an important role of maternal EPA, DHA, DGLA or AA in the association of short interpregnancy intervals with birth weight and SGA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Intervalo entre Nascimentos
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Peso ao Nascer
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Recém-Nascido Pequeno para a Idade Gestacional
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Fenômenos Fisiológicos da Nutrição Materna
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Ácidos Graxos Insaturados
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Newborn
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Pregnancy
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article