Clinical applications of growth factors in bone injuries: experience with BMPs.
Injury
; 44 Suppl 1: S34-9, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-23351868
ABSTRACT
The management of open fractures and delayed or non unions continue to be complicated by high rates of treatment failure and significant patient disability and dissatisfaction. The use of bone morphogenetic proteins (BMPs) in the treatment of these injuries has been assessed by several authors. BMPs induce the process of bone healing by recruiting bone-forming cells to the area of lesion. The use of BMP currently has two FDA-approved indications treatment of open tibial fractures treated with intramedullary fixation and treatment of tibia long bone non-union. Despite this limited target, off-label BMP use continues to push the spectrum for new applications. This review describes the current evidence for the use of BMPs in open fractures and non-unions.
Texto completo:
1
Eixos temáticos:
Pesquisa_clinica
Base de dados:
MEDLINE
Assunto principal:
Fraturas da Tíbia
/
Consolidação da Fratura
/
Proteína Morfogenética Óssea 2
/
Proteína Morfogenética Óssea 7
/
Fixação Interna de Fraturas
/
Fraturas Expostas
/
Fraturas não Consolidadas
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article