Deoxyribonucleoside triphosphate pool levels in three cell strains of human chromosome instability syndromes: ataxia telangiectasia (GM2052), Bloom's syndrome (GM1492), and Fanconi's anemia (GM368).
Cancer Biochem Biophys
; 11(1): 69-77, 1990 Jan.
Article
em En
| MEDLINE
| ID: mdl-2337882
ABSTRACT
Deoxyribonucleoside triphosphate (dNTP) pool sizes were determined in cell strains derived from patients with the genetic diseases ataxia telangiectasia (GM2052), Bloom's syndrome (GM1492), and Fanconi's anemia (GM368), and were compared to the dNTP pools in a normal human fibroblast cell strain (253/79). In addition, the effect of deoxythymidine on both dNTP pool levels and cell growth was examined. The three mutant cell strains differed only slightly from the normal cell strain. The cellular characteristics of the cell strains, such as chromosome instability, are apparently not an effect of dNTP pool imbalance.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Bloom
/
Ataxia Telangiectasia
/
Desoxirribonucleotídeos
/
Anemia de Fanconi
/
Anemia Aplástica
Limite:
Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article