Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan.
BMC Infect Dis
; 13: 68, 2013 Feb 05.
Article
em En
| MEDLINE
| ID: mdl-23384348
ABSTRACT
BACKGROUND:
The US military has seen steady increases in multidrug-resistant (MDR) gram-negative bacteria (GNB) infections in casualties from Iraq and Afghanistan. This study evaluates the prevalence of MDR GNB colonization in US military personnel.METHODS:
GNB colonization surveillance of healthy, asymptomatic military personnel (101 in the US and 100 in Afghanistan) was performed by swabbing 7 anatomical sites. US-based personnel had received no antibiotics within 30 days of specimen collection, and Afghanistan-based personnel were receiving doxycycline for malaria chemoprophylaxis at time of specimen collection. Isolates underwent genotypic and phenotypic characterization.RESULTS:
The only colonizing MDR GNB recovered in both populations was Escherichia coli (p=0.01), which was seen in 2% of US-based personnel (all perirectal) and 11% of Afghanistan-based personnel (10 perirectal, 1 foot+groin). Individuals with higher off-base exposures in Afghanistan did not show a difference in overall GNB colonization or MDR E. coli colonization, compared with those with limited off-base exposures.CONCLUSION:
Healthy US- and Afghanistan-based military personnel have community onset-MDR E. coli colonization, with Afghanistan-based personnel showing a 5.5-fold higher prevalence. The association of doxycycline prophylaxis or other exposures with antimicrobial resistance and increased rates of MDR E. coli colonization needs further evaluation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Portador Sadio
/
Farmacorresistência Bacteriana Múltipla
/
Escherichia coli
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Infecções por Escherichia coli
/
Militares
/
Antibacterianos
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
/
Male
País como assunto:
America do norte
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Asia
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article