Genome of the Chinese tree shrew.
Nat Commun
; 4: 1426, 2013.
Article
em En
| MEDLINE
| ID: mdl-23385571
ABSTRACT
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as models for a variety of human disorders depression, myopia, hepatitis B and C virus infections, and hepatocellular carcinoma, to name a few. Here we present a publicly available annotated genome sequence for the Chinese tree shrew. Phylogenomic analysis of the tree shrew and other mammalians highly support its close affinity to primates. By characterizing key factors and signalling pathways in nervous and immune systems, we demonstrate that tree shrews possess both shared common and unique features, and provide a genetic basis for the use of this animal as a potential model for biomedical research.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tupaia
/
Genoma
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article