Vascular endothelial growth factor induces growth of uterine cervix and immune cell recruitment in mice.
J Endocrinol
; 217(1): 83-94, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23386058
ABSTRACT
Knowledge of uterine cervical epithelial biology and factors that influence its events may be critical in understanding the process of cervical remodeling (CR). Here, we examine the impact of exogenous vascular endothelial growth factor (VEGF) on uterine cervical epithelial growth in mice (nonpregnant and pregnant) treated with VEGF agents (recombinant and inhibitor) using a variety of morphological and molecular techniques. Exogenous VEGF altered various uterine cervical epithelial cellular events, including marked induction of growth, edema, increase in inter-epithelial paracellular space, and recruitment of immune cells to the outer surface of epithelial cells (cervical lumen). We conclude that VEGF induces multiple alterations in the uterine cervical epithelial tissues that may play a role in local immune surveillance and uterine cervical growth during CR.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Colo do Útero
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Fator A de Crescimento do Endotélio Vascular
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Células Epiteliais
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Vigilância Imunológica
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article