Characterization of ovine Nectin-4, a novel peste des petits ruminants virus receptor.
J Virol
; 87(8): 4756-61, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23388720
ABSTRACT
Small ruminants infected with peste des petits ruminants virus exhibit lesions typical of epithelial infection and necrosis. However, the only established host receptor for this virus is the immune cell marker signaling lymphocyte activation molecule (SLAM). We have confirmed that the ovine Nectin-4 protein, when overexpressed in epithelial cells, permits efficient replication of PPRV. Furthermore, this gene was predominantly expressed in epithelial tissues and encoded by multiple haplotypes in sheep breeds from around the world.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Virais
/
Moléculas de Adesão Celular
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Vírus da Peste dos Pequenos Ruminantes
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Ligação Viral
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article