Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives.
J Enzyme Inhib Med Chem
; 29(2): 205-14, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-23391169
ABSTRACT
Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4-chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In addition, thioamide derivatives (6a-g) have higher growth inhibition than their carboxamide analogs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Tioamidas
/
Compostos Benzidrílicos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article