Highly efficient asymmetric synthesis of α,ß-epoxy esters via one-pot organocatalytic epoxidation and oxidative esterification.
Org Biomol Chem
; 11(11): 1815-7, 2013 Mar 21.
Article
em En
| MEDLINE
| ID: mdl-23396575
ABSTRACT
Highly enantioselective synthesis of α,ß-epoxy esters was achieved via one-pot organocatalytic epoxidation and consequent oxidative esterification. Excellent enantioselectivities (up to 99% ee) and good yields were obtained for a variety of α,ß-epoxy esters. The method was readily scaled. Furthermore the product was applied towards the synthesis of (-)-clausenamide with excellent enantioselectivities (>99% ee).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Azóis
/
Compostos de Epóxi
/
Ésteres
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article