Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives.
Bioorg Med Chem Lett
; 23(6): 1803-7, 2013 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-23403080
ABSTRACT
Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Antifúngicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article