The impact of adverse life events on clinical features and interaction with gene variants in mood disorder patients.
Psychopathology
; 46(6): 384-9, 2013.
Article
em En
| MEDLINE
| ID: mdl-23407025
ABSTRACT
BACKGROUND:
Adverse life events are precipitating and maintenance factors for mood and anxiety disorders. However, the impact of such events on clinical features and treatment response is still unclear. SAMPLING ANDMETHODS:
The aim of this study was to investigate whether specific adverse events (early parental loss and physical abuse) influence clinical features in a sample of 1,336 mood disorder patients, and whether genetic parameters interact with adverse events to influence treatment outcomes in a subsample of 252 subjects. Participants were collected in the context of a European multicenter study and treated with antidepressants at adequate doses for at least 4 weeks. We focused on two genes (BDNF and CREB1) due to prior evidence of association with treatment outcomes in the same sample.RESULTS:
Patients with a history of physical abuse had higher suicidal risk (including history of attempts), comorbid panic disorder, posttraumatic stress disorder and alcohol dependence compared to non-abused patients. Experience of early parental loss was a less detrimental type of life stressor. Treatment response was not affected by adverse events. No gene-environment interaction was found with genetic variations, using a corrected significance level.CONCLUSIONS:
A limitation of the present study is that the subsample is too small for detecting gene-environment interactions. The clinical message of our findings is that mood disorder patients with a history of physical abuse showed a worse clinical profile, characterized by higher comorbid Axis I psychopathology and increased suicidal behavior.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
/
Transtornos do Humor
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Interação Gene-Ambiente
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Acontecimentos que Mudam a Vida
Tipo de estudo:
Clinical_trials
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Etiology_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article