Extracellular signal-regulated kinase and glycogen synthase kinase 3ß regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.

Tyagarajan, Shiva K; Ghosh, Himanish; Yévenes, Gonzalo E; Imanishi, Susumu Y; Zeilhofer, Hanns Ulrich; Gerrits, Bertran; Fritschy, Jean-Marc

Tyagarajan, Shiva K; Ghosh, Himanish; Yévenes, Gonzalo E; Imanishi, Susumu Y; Zeilhofer, Hanns Ulrich; Gerrits, Bertran; Fritschy, Jean-Marc.

Afiliação

Tyagarajan SK; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Zurich, 8057 Switzerland. Electronic address: tyagarajan@pharma.uzh.ch.
Ghosh H; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Zurich, 8057 Switzerland.
Yévenes GE; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland.
Imanishi SY; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Zeilhofer HU; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Zurich, 8057 Switzerland; Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, 8093 Switzerland.
Gerrits B; Functional Genomics Center Zurich, 8057 Zurich, Switzerland.
Fritschy JM; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Zurich, 8057 Switzerland.

J Biol Chem ; 288(14): 9634-9647, 2013 Apr 05.

Article em En | MEDLINE | ID: mdl-23408424

Assuntos

Calpaína/metabolismo; Proteínas de Transporte/metabolismo; Quinase 3 da Glicogênio Sintase/metabolismo; Proteínas de Membrana/metabolismo; Proteína Quinase 3 Ativada por Mitógeno/metabolismo; Animais; Encéfalo/metabolismo; Eletrofisiologia/métodos; Glicogênio Sintase Quinase 3 beta; Células HEK293; Hipocampo/metabolismo; Humanos; Imunoprecipitação/métodos; Espectrometria de Massas/métodos; Modelos Biológicos; Mutagênese Sítio-Dirigida; Neurônios/metabolismo; Técnicas de Patch-Clamp; Fenótipo; Plasmídeos/metabolismo; Ratos; Sinapses/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Calpaína / Proteínas de Transporte / Quinase 3 da Glicogênio Sintase / Proteína Quinase 3 Ativada por Mitógeno / Proteínas de Membrana Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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