Retention or inversion in stereospecific nickel-catalyzed cross-coupling of benzylic carbamates with arylboronic esters: control of absolute stereochemistry with an achiral catalyst.
J Am Chem Soc
; 135(9): 3303-6, 2013 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-23414579
ABSTRACT
Stereospecific coupling of benzylic carbamates and pivalates with aryl- and heteroarylboronic esters has been developed. The reaction proceeds with selective inversion or retention at the electrophilic carbon, depending on the nature of the ligand. Tricyclohexylphosphine ligand provides the product with retention, while an N-heterocyclic carbene ligand provides the product with inversion.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Compostos de Benzil
/
Ácidos Borônicos
/
Carbamatos
/
Ésteres
/
Metano
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article