Synthesis of heterocyclic terpenoids by promiscuous squalene-hopene cyclases.
Chembiochem
; 14(4): 436-9, 2013 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-23418022
ABSTRACT
PROMISCUOUS ENZYMES The substrate promiscuity of squalene-hopene cyclases has been explored and applied in the enzyme-catalyzed synthesis of heterocyclic terpenoids. Features of this work include cyclization reactions without pyrophosphate activation, and stereospecific ring closure of substrates of varying chain length and terminal nucleophile. This provides a biocatalytic alternative to traditional chemical catalysts.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
Transferases Intramoleculares
/
Alicyclobacillus
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article