Recursive partitioning analysis for the prediction of stereotactic radiosurgery brain metastases lesion control.
Oncologist
; 18(3): 330-5, 2013.
Article
em En
| MEDLINE
| ID: mdl-23429647
ABSTRACT
PURPOSE:
The objective of this investigation was to identify independent pretreatment factors that predict for control of local brain metastases (BM) in a large single-institution series of patients receiving stereotactic radiosurgery (SRS). Recursive partitioning analysis was used to potentially identify a class of patients with durable lesion control characteristics.METHODS:
A retrospective SRS database containing baseline characteristics, treatment details, and follow-up data of newly diagnosed patients with 1-3 BM (on magnetic resonance imaging) treated with linear accelerator-based SRS was created. Three study endpoints were used time to progression (primary endpoint, individual lesion progression; n = 536), time to first progression (secondary endpoint, first lesion progression on an individual patient basis; n = 380), and overall survival (secondary endpoint; n = 380). Recursive partitioning analysis (RPA) was performed to identify predictors of time to progression.RESULTS:
Multivariable analysis demonstrated that lesion aspect/phenotype and radiotherapy schedule were independent factors associated with both progression outcomes. Presence of tumor necrosis was found to be associated with a significant hazard of progression (hazard ratio >3), whereas use of the most intense radiotherapy fractionation schedule (21 Gy in one fraction) was associated with significant reductions in progression (hazard ratio <0.3). RPA using SRS dose and lesion aspect/phenotype was created and described three distinct prognostic groups.CONCLUSIONS:
RPA of a large retrospective database of patients receiving SRS confirmed previous observations regarding the importance of SRS dose and lesion aspect/phenotype in lesion control and overall survival. The SRS lesion analysis may help to stratify future clinical trials and better define patient care options and prognosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Radiocirurgia
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article