Changing glucocorticoid action: 11ß-hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation.

Chapman, Karen E; Coutinho, Agnes E; Zhang, Zhenguang; Kipari, Tiina; Savill, John S; Seckl, Jonathan R

Chapman, Karen E; Coutinho, Agnes E; Zhang, Zhenguang; Kipari, Tiina; Savill, John S; Seckl, Jonathan R.

Afiliação

Chapman KE; University/BHF Centre for Cardiovascular Sciences, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Electronic address: Karen.Chapman@ed.ac.uk.

J Steroid Biochem Mol Biol ; 137: 82-92, 2013 Sep.

Article em En | MEDLINE | ID: mdl-23435016

Assuntos

11-beta-Hidroxiesteroide Desidrogenase Tipo 1/metabolismo; Anti-Inflamatórios/uso terapêutico; Glucocorticoides/uso terapêutico; Inflamação/tratamento farmacológico; Doença Aguda; Doença Crônica; Humanos; Inflamação/enzimologia

Palavras-chave

11ß-HSD; 11ß-Hydroxysteroid dehydrogenase; 11ß-hydroxysteroid dehydrogenase; Arthritis; C/EBP; CCAAT/enhancer binding protein; EGR-1; Glucocorticoid; H6PD; HPA; IL; Inflammation; LPS; MCP; Macrophage; Mineralocorticoid; NF-κB; TNF-α; VCAM; early growth response-1; hexose-6-phosphate dehydrogenase; hypothalamicpituitaryadrenal; interleukin; lipopolysaccharide; monocyte chemotactic protein; nuclear factor kappa-light-chain-enhancer of activated B cells; tumour necrosis factor-α; vascular cell adhesion molecule

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 11-beta-Hidroxiesteroide Desidrogenase Tipo 1 / Glucocorticoides / Inflamação / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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