[A study of interleukin-10 gene polymorphisms in Miao, Dong and Buyi ethnics of Guizhou].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 30(1): 116-20, 2013 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-23450495
ABSTRACT
OBJECTIVE:
To investigate allelic frequencies of interluekin-10 (IL-10) gene promoter in Miao, Dong and Buyi ethnics of Guizhou.METHODS:
TaqMan MGB-based real-time PCR was used to determine the genotypes of IL-10 -819 and IL-10 -592 in 589 Miao, Dong and Buyi ethnics of Guizhou.RESULTS:
The allelic frequency of IL-10 -819 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. Allelic frequencies of IL-10 -592 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. In Miao, Dong and Buyi ethnics, the distributions of genotype frequencies of IL-10 -819 and IL-10 -592 were statistically different from Han ethnics from Guizhou and Taiwan of China as well as South Koreans.CONCLUSION:
There is a heterogeneity in the frequencies of polymorphisms of IL-10 promoter among different ethnic groups.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interleucina-10
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
Limite:
Humans
País como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article