Synthesis and antiproliferative activity of 2,5-bis(3'-indolyl)pyrroles, analogues of the marine alkaloid nortopsentin.
Mar Drugs
; 11(3): 643-54, 2013 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-23455514
ABSTRACT
2,5-bis(3'-Indolyl)pyrroles, analogues of the marine alkaloid nortopsentin, were conveniently prepared through a three step procedure in good overall yields. Derivatives 1a and 1b exhibited concentration-dependent antitumor activity towards a panel of 42 human tumor cell lines with mean IC50 values of 1.54 µM and 0.67 µM, respectively. Investigating human tumor xenografts in an ex-vivo clonogenic assay revealed selective antitumor activity, whereas sensitive tumor models were scattered among various tumor histotypes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Imidazóis
/
Indóis
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Antineoplásicos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article