Targeting the skin for microneedle delivery of influenza vaccine.
Adv Exp Med Biol
; 785: 121-32, 2013.
Article
em En
| MEDLINE
| ID: mdl-23456844
ABSTRACT
Influenza infection represents a major socioeconomic burden worldwide. Skin represents a new target that has gained much attention in recent years for delivery of influenza vaccine as an alternative to the conventional intramuscular route of immunization. In this review we describe different microneedle vaccination approaches used in vivo, including metal and dissolving microneedle patches that have demonstrated promising results. Additionally we analyze the immunological basis for microneedle skin immunization and targeting of the skin's dense population of antigen presenting cells, their role, characterization, and function. Additionally we analyze the importance of inflammatory signaling in the skin after microneedle delivery.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Injeções Intradérmicas
/
Vacinação
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Influenza Humana
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article