Estimation of genetic parameters and detection of quantitative trait loci for metabolites in Danish Holstein milk.
J Dairy Sci
; 96(5): 3285-95, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23497994
ABSTRACT
Small components and metabolites in milk are significant for the utilization of milk, not only in dairy food production but also as disease predictors in dairy cattle. This study focused on estimation of genetic parameters and detection of quantitative trait loci for metabolites in bovine milk. For this purpose, milk samples were collected in mid lactation from 371 Danish Holstein cows in first to third parity. A total of 31 metabolites were detected and identified in bovine milk by using (1)H nuclear magnetic resonance (NMR) spectroscopy. Cows were genotyped using a bovine high-density single nucleotide polymorphism (SNP) chip. Based on the SNP data, a genomic relationship matrix was calculated and used as a random factor in a model together with 2 fixed factors (herd and lactation stage) to estimate the heritability and breeding value for individual metabolites in the milk. Heritability was in the range of 0 for lactic acid to >0.8 for orotic acid and ß-hydroxybutyrate. A single SNP association analysis revealed 7 genome-wide significant quantitative trait loci [malonate Bos taurus autosome (BTA)2 and BTA7; galactose-1-phosphate BTA2; cis-aconitate BTA11; urea BTA12; carnitine BTA25; and glycerophosphocholine BTA25]. These results demonstrate that selection for metabolites in bovine milk may be possible.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bovinos
/
Locos de Características Quantitativas
/
Leite
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article