SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine.
Mol Aspects Med
; 34(2-3): 360-72, 2013.
Article
em En
| MEDLINE
| ID: mdl-23506877
ABSTRACT
The exocytotic release of neurotransmitters requires active transport into synaptic vesicles and other types of secretory vesicles. Members of the SLC18 family perform this function for acetylcholine (SLC18A3, the vesicular acetylcholine transporter or VAChT) and monoamines such as dopamine and serotonin (SLC18A1 and 2, the vesicular monoamine transporters VMAT1 and 2, respectively). To date, no specific diseases have been attributed to a mutation in an SLC18 family member; however, polymorphisms in SLC18A1 and SLC18A2 may confer risk for some neuropsychiatric disorders. Additional members of this family include SLC18A4, expressed in insects, and SLC18B1, the function of which is not known. SLC18 is part of the DrugH(+) Antiporter-1 Family (DHA1, TCID 2.A.1.2) within the Major Facilitator Superfamily (MFS, TCID 2.A.1).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Conformação Proteica
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Modelos Moleculares
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Regulação da Expressão Gênica
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Família Multigênica
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Proteínas Vesiculares de Transporte de Acetilcolina
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Doenças do Sistema Nervoso
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article