CD4 and CD8 T cells directly recognize murine gammaherpesvirus 68-immortalized cells and prevent tumor outgrowth.
J Virol
; 87(10): 6051-4, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23514885
ABSTRACT
There has been extensive research regarding T cell recognition of Epstein-Barr virus-transformed cells; however, less is known regarding the recognition of B cells immortalized by gamma-2 herpesviruses. Here we show that B cells immortalized by murine gammaherpesvirus 68 (MHV-68, γHV-68) can be controlled by either CD4 or CD8 T cells in vivo. We present evidence for the direct recognition of infected B cells by CD4 and CD8 T cells. These data will help in the development of immunotherapeutic approaches combating gamma-2 herpesvirus-related disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Linfócitos T CD4-Positivos
/
Transformação Celular Viral
/
Rhadinovirus
/
Linfócitos T CD8-Positivos
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article