Robust cellular reprogramming occurs spontaneously during liver regeneration.
Genes Dev
; 27(7): 719-24, 2013 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-23520387
ABSTRACT
Cellular reprogramming-the ability to interconvert distinct cell types with defined factors-is transforming the field of regenerative medicine. However, this phenomenon has rarely been observed in vivo without exogenous factors. Here, we report that activation of Notch, a signaling pathway that mediates lineage segregation during liver development, is sufficient to reprogram hepatocytes into biliary epithelial cells (BECs). Moreover, using lineage tracing, we show that hepatocytes undergo widespread hepatocyte-to-BEC reprogramming following injuries that provoke a biliary response, a process requiring Notch. These results provide direct evidence that mammalian regeneration prompts extensive and dramatic changes in cellular identity under injury conditions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hepatócitos
/
Células Epiteliais
/
Regeneração Hepática
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article