Bioreactor engineering of stem cell environments.
Biotechnol Adv
; 31(7): 1020-31, 2013 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-23531529
ABSTRACT
Stem cells hold promise to revolutionize modern medicine by the development of new therapies, disease models and drug screening systems. Standard cell culture systems have limited biological relevance because they do not recapitulate the complex 3-dimensional interactions and biophysical cues that characterize the in vivo environment. In this review, we discuss the current advances in engineering stem cell environments using novel biomaterials and bioreactor technologies. We also reflect on the challenges the field is currently facing with regard to the translation of stem cell based therapies into the clinic.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
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Reatores Biológicos
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Nicho de Células-Tronco
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Engenharia Celular
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article