BIM, PUMA, and the achilles' heel of oncogene addiction.
Sci Signal
; 6(268): pe12, 2013 Mar 26.
Article
em En
| MEDLINE
| ID: mdl-23532333
ABSTRACT
Cancer cells undergo extensive genetic and epigenetic rewiring to support the malignant phenotype, and yet cell survival and proliferation often remain dependent on one or a limited number of driver mutations. This is the concept of oncogene addiction, the elucidation of which has led to substantial progress in therapeutic interventions. However, because resistance mechanisms often emerge, explicating the pathways that connect therapeutic oncogene inactivation to the cell death machinery is critical to exploiting additional synthetic lethal opportunities.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Proteínas Proto-Oncogênicas
/
Sistemas de Liberação de Medicamentos
/
Proteínas Reguladoras de Apoptose
/
Proteínas de Membrana
/
Modelos Biológicos
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article