Total synthesis of (-)-dihydroprotolichesterenic acid via diastereoselective conjugate addition to chiral fumarates.
Tetrahedron Lett
; 54(16): 2074-2076, 2013 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-23539490
ABSTRACT
A diastereoselective conjugate addition of a variety of monoorganocuprates, Li[RCuI], to chiral fumarates to provide funtionalized succinates has been developed. The utility of this reaction is demonstrated in a concise total synthesis of (-)-dihydroprotolichesterenic acid that required only four steps and proceeded in an overall 31% yield.
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MEDLINE
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En
Ano de publicação:
2013
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Article