Myositis with antimitochondrial antibodies diagnosed by rectus abdominis muscle biopsy.
Muscle Nerve
; 47(5): 766-8, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23553600
ABSTRACT
INTRODUCTION:
Antimitochondrial antibodies are autoantibodies detected in 90% of primary biliary cirrhosis (PBC) patients. Some PBC cases are complicated by myositis, which is difficult to confirm due to minimal histological evidence of inflammation in limb muscles.METHODS:
Our aim was to determine the extent of inflammatory changes in a truncal muscle biopsy specimen from a PBC patient.RESULTS:
A 48-year-old woman with a 5-year history of atrial fibrillation and chronic heart failure was evaluated for elevated serum creatine kinase level. Antimitochondrial M2 antibodies were detected, and PBC was diagnosed. A biceps brachii biopsy specimen showed mild, non-specific myogenic changes; a second biopsy was performed on the rectus abdominis muscle, which showed typical inflammatory changes. Myositis with antimitochondrial M2 antibodies was confirmed.CONCLUSIONS:
In myositis patients with antimitochondrial M2 antibodies, muscles of the extremities are involved to a lesser extent. Radiological and histological examination focusing on truncal muscles, including a biopsy, is important.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Músculo Esquelético
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Cirrose Hepática Biliar
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Mitocôndrias
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Miosite
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
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Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article