Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents.
Eur J Med Chem
; 63: 645-54, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23567953
ABSTRACT
Some novel 1,3,4-trisubstituted pyrazoles were synthesized and screened for their anti-inflammatory and analgesic activities as well as their ulcerogenic liability. They showed anti-inflammatory and analgesic activities with better GIT tolerance than the standard drug phenylbutazone. In addition, IC50 values for 5e and 8e were recorded. Compound 5e was found to be the most active one as anti-inflammatory and analgesic agent. On the other hand, COX-1/COX-2 isozyme selectivity was also done which showed equal inhibition to both isoforms.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Inibidores de Ciclo-Oxigenase
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Analgésicos
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article