A crucial role for Lyn in TIMP-1 erythroid cell survival signalling pathway.
FEBS Lett
; 587(10): 1524-8, 2013 May 21.
Article
em En
| MEDLINE
| ID: mdl-23583449
ABSTRACT
TIMP-1, a well-known MMP inhibitor, displays other biological activities such as cell survival, proliferation and differentiation in hematopoietic cells. In this report, we investigated the role of the Src-related kinase Lyn in TIMP-1 induced UT-7 erythroleukemic cell survival. We showed that (i) tyrosine 507 of Lyn was dephosphorylated and Lyn kinase activity enhanced by TIMP-1, (ii) Lyn silencing suppressed TIMP-1 anti-apoptotic activity and (iii) Lyn was activated upstream the JAK2/PI 3-kinase/Akt pathway. Our data suggest a novel role for Lyn in erythroid cell survival.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinases da Família src
/
Inibidor Tecidual de Metaloproteinase-1
/
Células Eritroides
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article