Evaluation of current rapid HIV test algorithms in Rakai, Uganda.
J Virol Methods
; 192(1-2): 25-7, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23583487
ABSTRACT
Rapid HIV tests are a crucial component of HIV diagnosis in resource limited settings. In Uganda, the Ministry of Health allows both serial and parallel HIV rapid testing using Determine, Stat-Pak and Uni-Gold. In serial testing, a non-reactive result on Determine ends testing. The performance of serial and parallel algorithms with Determine and Stat-Pak test kits was assessed. A cross-sectional diagnostic test accuracy evaluation using three rapid HIV test kits as per the recommended parallel test algorithm was followed by EIA-WB testing with estimates of the performance of serial testing algorithm. In 2520 participants tested by parallel rapid algorithms, 0.6% had weakly reactive result. Parallel testing had 99.7% sensitivity and 99.8% specificity. If Stat-Pak was used as the first screening test for a serial algorithm, the sensitivity was 99.6% and specificity was 99.7%. However, if Determine was used as the screening test, sensitivity was 97.3% and specificity was 99.9%. Serial testing with Stat-Pak as the initial screening test performed as well as parallel testing, but Determine was a less sensitive screen. Serial testing could be cost saving.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Infecções por HIV
/
Testes Diagnósticos de Rotina
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Adolescent
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Adult
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Female
/
Humans
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Male
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Middle aged
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article