Association analysis of the HLA-C gene in Japanese alopecia areata.
Immunogenetics
; 65(7): 553-7, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23588886
ABSTRACT
Alopecia areata (AA) is an organ-specific and cell-mediated autoimmune disease involving hair loss, but its pathogenesis remains poorly understood. Many autoimmune diseases are genetically associated with alleles of the human leukocyte antigen (HLA) genes within the major histocompatibility complex. Associations between AA and HLA genes were previously observed in some different ethnic groups. However, the results were inconsistent, and a primary susceptibility HLA gene and/or region has not yet been assigned for AA. The aim of this study was to evaluate whether an allele of the HLA-C locus, HLA-C*0704, which was strongly associated with AA in Chinese Hans, could be replicated in the Japanese population. The HLA-C locus was genotyped by the SSO method using 156 AA patients and 560 healthy controls. As a consequence, among the 17 alleles detected, only two alleles, C*0401 (OR = 2.25, CI 95 % = 1.35-3.75, P = 1.84E-03) and C*1502 (OR = 2.52, CI 95 % = 1.37-4.64, P = 2.90E-03), were significantly associated with AA after Bonferroni correction. Further, the stratification analysis suggested that C*0401, C*0702, and C*1502 represented different AA genetic risk factors in each sub-phenotype.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA-C
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Povo Asiático
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Alopecia em Áreas
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article