Cooked common beans (Phaseolus vulgaris) protect against ß-cell damage in streptozotocin-induced diabetic rats.
Plant Foods Hum Nutr
; 68(2): 207-12, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23595343
ABSTRACT
Diabetes is a disease characterized by a hyperglycemic stage that leads to a chronic inflammatory state. We evaluated the in vivo effect of a diet supplemented with 25 % cooked black bean cultivar Negro 8025 (N8025) flour in streptozotocin-induced diabetic rats. The effect was assessed before (preventive-treatment) and after (treatment) the onset of diabetes. There is a significant decrease of total phenolic, tannins and anthocyanins content after cooking, and the concentration of most of the single phenols analyzed are only slightly decreased. The treatment group showed a significant reduction of glucose (22.8 %), triglycerides (21.9 %), total cholesterol (29.9 %) and LDL (56.1 %) that correlates with a protection of pancreatic ß-cells. The diet with N8025 flour before the induction of diabetes did not exert a protective effect (glucose levels are similar to the diabetic control) but they have low levels of total cholesterol (47.5 %) and LDL (56.1 %). The preventive-treatment group did not inhibit the increase of TNF-α and IL-1ß, whereas the treatment group did, compared to the diabetic control. Therefore, N8025 bean supplementation can be recommended to control diabetes.
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Base de dados:
MEDLINE
Assunto principal:
Phaseolus
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Diabetes Mellitus Experimental
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Células Secretoras de Insulina
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article