Semaphorin 3F forms an anti-angiogenic barrier in outer retina.
FEBS Lett
; 587(11): 1650-5, 2013 Jun 05.
Article
em En
| MEDLINE
| ID: mdl-23603393
ABSTRACT
Semaphorins are known modulators of axonal sprouting and angiogenesis. In the retina, we identified a distinct and almost exclusive expression of Semaphorin 3F in the outer layers. Interestingly, these outer retinal layers are physiologically avascular. Using functional in vitro models, we report potent anti-angiogenic effects of Semaphorin 3F on both retinal and choroidal vessels. In addition, human retinal pigment epithelium isolates from patients with pathologic neovascularization of the outer retina displayed reduced Semaphorin 3F expression in 10 out of 15 patients. Combined, these results elucidate a functional role for Semaphorin 3F in the outer retina where it acts as a vasorepulsive cue to maintain physiologic avascularity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Angiostáticas
/
Segmento Externo das Células Fotorreceptoras da Retina
/
Proteínas de Membrana
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article