Pump-probe nonlinear phase dispersion spectroscopy.
Opt Express
; 21(8): 9353-64, 2013 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-23609646
ABSTRACT
Pump-probe microscopy is an imaging technique that delivers molecular contrast of pigmented samples. Here, we introduce pump-probe nonlinear phase dispersion spectroscopy (PP-NLDS), a method that leverages pump-probe microscopy and spectral-domain interferometry to ascertain information from dispersive and resonant nonlinear effects. PP-NLDS extends the information content to four dimensions (phase, amplitude, wavelength, and pump-probe time-delay) that yield unique insight into a wider range of nonlinear interactions compared to conventional methods. This results in the ability to provide highly specific molecular contrast of pigmented and non-pigmented samples. A theoretical framework is described, and experimental results and simulations illustrate the potential of this method. Implications for biomedical imaging are discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Análise Espectral
/
Imagem Molecular
/
Microscopia
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article