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Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 ß4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.
Sugiyama, Hirokazu; Mizutani, Kiyohito; Kurita, Souichi; Okimoto, Naomasa; Shimono, Yohei; Takai, Yoshimi.
Afiliação
  • Sugiyama H; Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Genes Cells ; 18(6): 519-28, 2013 Jun.
Article em En | MEDLINE | ID: mdl-23611113
Nectin-like molecule 4 (Necl-4)/CADM4, a transmembrane cell-cell adhesion molecule with three Ig-like domains, was shown to serve as a tumor suppressor, but its mode of action has not been elucidated. In this study, we showed that Necl-4 interacted in cis with ErbB3 through their extracellular regions, recruited PTPN13 and inhibited the heregulin-induced activation of the ErbB2/ErbB3 signaling. In addition, we extended our previous finding that Necl-4 interacts in cis with integrin α6 ß4 through their extracellular regions and found that Necl-4 inhibited the phorbol ester-induced disassembly of hemidesmosomes. These results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulinas / Transdução de Sinais / Moléculas de Adesão Celular / Receptor ErbB-2 / Receptor ErbB-3 / Hemidesmossomos / Integrina alfa6beta4 Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulinas / Transdução de Sinais / Moléculas de Adesão Celular / Receptor ErbB-2 / Receptor ErbB-3 / Hemidesmossomos / Integrina alfa6beta4 Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article