Expression and modification proteomics during skeletal muscle ageing.
Biogerontology
; 14(3): 339-52, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23624703
ABSTRACT
Skeletal muscle ageing is characterized by a progressive and dramatic loss of muscle mass and strength leading to decreased muscular function resulting in muscle weakness which is often referred to as sarcopenia. Following the standardisation of "omics" approaches to study the genome (genomics) and the transcriptome (transcriptomics), the study of the proteins encoded by the genome, referred to as proteomics, is a tremendous challenge. Unlike the genome, the proteome varies in response to many physiological or pathological factors. In addition, the proteome is orders of magnitude more complex than the transcriptome due to post-translational modifications, protein oxidation and limited protein degradation. Proteomic studies, including the analysis of protein abundance as well as post-translational modified proteins have been shown to provide valuable information to unravel the key molecular pathways implicated in complex biological processes, such as tissue and organ ageing. In this article, we will describe proteomic approaches for the analysis of protein abundance as well as the specific protein targets for oxidative damage upon oxidative stress and/or during skeletal muscle ageing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Processamento de Proteína Pós-Traducional
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Regulação da Expressão Gênica
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Músculo Esquelético
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Proteômica
/
Proteínas Musculares
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article