IgG1 thioether bond formation in vivo.

Zhang, Qingchun; Schenauer, Matthew R; McCarter, John D; Flynn, Gregory C

Zhang, Qingchun; Schenauer, Matthew R; McCarter, John D; Flynn, Gregory C.

Afiliação

Zhang Q; Departments of Process and Product Development, Thousand Oaks, California 91320.
Schenauer MR; Departments of Process and Product Development, Thousand Oaks, California 91320.
McCarter JD; Therapeutic Discovery, Amgen Inc., Thousand Oaks, California 91320.
Flynn GC; Departments of Process and Product Development, Thousand Oaks, California 91320. Electronic address: gflynn@amgen.com.

J Biol Chem ; 288(23): 16371-16382, 2013 Jun 07.

Article em En | MEDLINE | ID: mdl-23625924

Assuntos

Imunoglobulina G/metabolismo; Cadeias kappa de Imunoglobulina/metabolismo; Cadeias lambda de Imunoglobulina/metabolismo; Sulfetos/metabolismo; Animais; Células CHO; Cricetinae; Cricetulus; Humanos; Imunoglobulina G/genética; Cadeias kappa de Imunoglobulina/genética; Cadeias lambda de Imunoglobulina/genética; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo

Palavras-chave

Antibodies; Disulfide; Drug Development; Light Chain; Mass Spectrometry (MS); Post Translational Modification

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfetos / Imunoglobulina G / Cadeias kappa de Imunoglobulina / Cadeias lambda de Imunoglobulina Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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