Measles outbreak in a pediatric oncology unit and the role of ribavirin in prevention of complications and containment of the outbreak.
Pediatr Blood Cancer
; 60(10): E122-4, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23629813
ABSTRACT
The role of oral ribavirin in treatment and containment of a measles outbreak in 15 children in an oncology unit is presented. Measles was diagnosed on clinical features and history of contact. Measles specific IgM ELISA and RNA were positive in 7 of 15 and 2 of 7 tested children, respectively. Duration of illness was longer in unimmunized as compared to immunized children (P = 0.02). Complications were higher in hematological malignancies (P = 0.025). Delay in starting ribavirin was associated with fatal complications (2 of 2 vs. 0 of 13, P = 0.009). Ribavirin prevented measles in all (21 of 21) patients exposed to the cases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Ribavirina
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Surtos de Doenças
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Sarampo
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article