Evaluation of 2'-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase.
Bioorg Med Chem Lett
; 23(11): 3354-7, 2013 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-23639543
ABSTRACT
Ribonucleoside phosphonate analogues containing 2'-α-fluoro modifications were synthesized and their potency evaluated against HCV RNA polymerase. The diphosphophosphonate (triphosphate equivalent) adenine and cytidine analogues displayed potent inhibition of the HCV polymerase in the range of 1.9-2.1 µM, but only modest cell-based activity in the HCV replicon. Pro-drugs of the parent nucleoside phosphonates improved the cell-based activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Ribonucleosídeos
/
RNA Polimerases Dirigidas por DNA
/
Hepacivirus
/
Organofosfonatos
/
Flúor
Tipo de estudo:
Evaluation_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article