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Phenotypic polarization of macrophages in atherosclerosis.
Leitinger, Norbert; Schulman, Ira G.
Afiliação
  • Leitinger N; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908-0735, USA. nl2q@virginia.edu
Arterioscler Thromb Vasc Biol ; 33(6): 1120-6, 2013 Jun.
Article em En | MEDLINE | ID: mdl-23640492
ABSTRACT
Macrophages orchestrate the inflammatory response in inflamed tissues, and recent work indicates that these cells can alter their phenotypes and functions accordingly in response to changes in the microenvironment. Initial work in models of cardiovascular disease used immunologic markers to characterize macrophage phenotypes present in atherosclerotic plaque, and these studies have lately been extended through the use of markers that are more specific for atherosclerosis and metabolic disease. Together, these studies have led to a novel view of the function of macrophages in the development of atherosclerosis that suggests dynamic plasticity. Understanding this plasticity and the ensuing macrophage heterogeneity could lead to novel strategies of pharmacological intervention to combat chronic inflammation in metabolic diseases. Most importantly, revealing the functional characteristics of individual macrophage phenotypes will lead to a better understanding of their contribution to lesion development and plaque stability.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica / Inflamação / Macrófagos Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica / Inflamação / Macrófagos Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article