Ascaris lumbricoides infection in urban schoolchildren: specific IgE and IL-10 production.
Allergol Immunopathol (Madr)
; 42(3): 206-11, 2014.
Article
em En
| MEDLINE
| ID: mdl-23648101
ABSTRACT
BACKGROUND:
Helminth infections and allergies are diseases with intense Th2 lymphocytes participation and characterised by a high IgE and Interleukin-(IL) IL-4, IL-5 production and eosinophilia. However, helminths also induce IL-10 production, which may alter the outcome of allergic diseases in infected patients.OBJECTIVE:
This experimental study analyses the relationship between IL-10 production by cell culture from geohelminth infected and non-infected children and specific IgE to Ascaris lumbricoides (Asc) or Blomia tropicalis (BT).METHODS:
IL-10 content in supernatant from peripheral blood mononuclear cell culture from nine helminth infected and eleven non-infected patients was determined by ELISA after in vitro stimulation with Asc or BT extracts.RESULTS:
A positive association was observed between total IgE levels and anti-Ascaris and anti-Blomia tropicalis specific IgE, independent of infection status. For both helminth-infected and non-infected groups, there was no difference in IL-10 production in response to Asc extract, even though anti-Ascaris IgE levels were higher in the latter group. In response to BT stimulus, a lower production of IL-10 by the geohelminth-infected group was observed, but with no relationship between IL-10 production and specific IgE to BT.CONCLUSION:
The results suggest that anti-Ascaris IgE in non-infected patients may be associated to a resistance to parasites. Levels of specific IgE to parasite antigens or B. tropicalis allergen were not impaired by IL-10 production in children from an urban area in which geohelminthiasis is endemic.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ascaríase
/
Imunoglobulina E
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Anticorpos Anti-Helmínticos
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Leucócitos Mononucleares
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Interleucina-10
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Ascaris lumbricoides
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Hipersensibilidade
Limite:
Animals
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Child
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article