Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: a meta-analysis.
J Affect Disord
; 150(1): 23-8, 2013 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-23648227
ABSTRACT
BACKGROUND:
Previous studies have implicated norepinephrine transporter (NET) gene polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide NET polymorphisms, T-182C (rs2242446) in the promoter region and G1287A (rs5569) in exon 9, were found to be associated with MDD in different populations. However, inconsistent and inconclusive results have also been obtained.METHODS:
In this study, we examined whether rs2242446 and rs5569 genetic variants are related to the etiology of MDD using a meta-analysis. Relevant case-control studies were retrieved by database searching and selected according to established inclusion criteria.RESULTS:
Eight articles were identified that tested the relationship between the NET T-182C and/or G1287A polymorphism and MDD. Statistical analyses revealed no significant association between these polymorphisms and MDD (OR=1.23, 95% CI=0.77-1.97, P=0.38 for T-182C; OR=1.00, 95% CI=0.78-1.29, P=0.99 for G1287A).LIMITATIONS:
The results must be treated with caution because of the small sample sizes of several included studies.CONCLUSIONS:
Our findings suggest that the NET T-182C and G1287A polymorphisms are not susceptibility factors for MDD.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Transtorno Depressivo Maior
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Proteínas da Membrana Plasmática de Transporte de Norepinefrina
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article