Radiation therapy for lymph node metastasis from extramammary Paget's disease.
J Eur Acad Dermatol Venereol
; 28(7): 873-7, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-23663098
ABSTRACT
BACKGROUND:
Inoperable patients with lymph node metastasis from extramammary Paget's disease (EMPD) have limited curative treatment options.OBJECTIVE:
The aim of this study was to review the efficacy and toxicity of radiation therapy for lymph node metastasis from EMPD.METHODS:
Eight EMPD patients with pelvic and inguinal lymph node metastasis, representing a total of 43 metastatic lymph nodes, underwent radiation therapy. Of these eight patients, two received radiation therapy as an initial treatment for EMPD and six for recurrence only in the lymph nodes after they had undergone surgery. Total doses of 45-61.2 Gy (median, 59.4 Gy) were delivered to metastatic lymph nodes in 25-34 fractions (median, 33 fractions).RESULTS:
Of the 43 metastatic lymph nodes in the eight patients, all but one had no progression at the median follow-up time of 22 months. The 2-year local control rates were 86% in all patients and 98% in all metastatic lymph nodes, respectively. No therapy-related toxicities of grade 3 or greater were observed.CONCLUSION:
Radiation therapy is effective and safe, and appears to offer a curative treatment option for lymph node metastasis from EMPD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Doença de Paget Extramamária
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Metástase Linfática
Tipo de estudo:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Aged
/
Aged80
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article