Superantigens induce IL-17 production from polarized Th1 clones.
Cytokine
; 63(1): 6-9, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23664273
ABSTRACT
Differentiation of naïve CD4(+) T cells has been considered to be an irreversible event and, in particular, the plasticity is believed to be completely lost in Th1 subset in vitro after multiple stimulations. However, here we demonstrate that highly polarized myelin oligodendrocyte glycoprotein (MOG)- and herpes simples virus-specific Th1 clones were still capable of producing IL-17 upon superantigen stimulation. Anti-MHC class-II and anti-TCR αß chains partially blocked superantigen-induced IL-17 production. These findings suggest that fully differentiated Th1 cells still have capability to produce cytokines of other Th subsets and production of IL-17 by MOG-specific Th1 cells may have implication in initiation and/or exacerbation of neurological autoimmune diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polaridade Celular
/
Superantígenos
/
Células Th1
/
Interleucina-17
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article