Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorg Med Chem Lett
; 23(12): 3662-6, 2013 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-23664874
Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the development candidate TAK-960. TAK-960 is currently undergoing Phase I evaluation in adult patients with advanced solid malignancies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Azepinas
/
Proteínas Proto-Oncogênicas
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Proteínas Serina-Treonina Quinases
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Proteínas de Ciclo Celular
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Inibidores de Proteínas Quinases
Limite:
Adult
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Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article