MicroRNA regulation of endothelial homeostasis and commitment-implications for vascular regeneration strategies using stem cell therapies.
Free Radic Biol Med
; 64: 52-60, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23665307
ABSTRACT
Human embryonic (hESC) and induced pluripotent (hiPSC) stem cells have broad therapeutic potential in the treatment of a range of diseases, including those of the vascular system. Both hESCs and hiPSCs have the capacity for indefinite self-renewal, in addition to their ability to differentiate into any adult cell type. These cells could provide a potentially unlimited source of cells for transplantation and, therefore, provide novel treatments, e.g. in the production of endothelial cells for vascular regeneration. MicroRNAs are short, noncoding RNAs that act posttranscriptionally to control gene expression and thereby exert influence over a wide range of cellular processes, including maintenance of pluripotency and differentiation. Expression patterns of these small RNAs are tissue specific, and changes in microRNA levels have often been associated with disease states in humans, including vascular pathologies. Here, we review the roles of microRNAs in endothelial cell function and vascular disease, as well as their role in the differentiation of pluripotent stem cells to the vascular endothelial lineage. Furthermore, we discuss the therapeutic potential of stem cells and how knowledge and manipulation of microRNAs in stem cells may enhance their capacity for vascular regeneration.
Palavras-chave
CVD; EC; EPC; Embryonic stem cells; Free radicals; Induced pluripotent stem cells; MicroRNA; Pluripotency; ROS; Regenerative medicine; VEGF; Vascular endothelial cells; cardiovascular disease; endothelial cell; endothelial progenitor cell; hESC; human embryonic stem cell; iPSC; induced pluripotent stem cell; mESC; miRNA; microRNA; murine embryonic stem cell; reactive oxygen species; vascular endothelial growth factor
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Vasculares
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Endotélio Vascular
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MicroRNAs
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Células Endoteliais
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Células-Tronco Embrionárias
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Células-Tronco Pluripotentes Induzidas
Limite:
Adult
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Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article