Synthesis of a new ent-cyclozonarone angular analog, and comparison of its cytotoxicity and apoptotic effects with ent-cyclozonarone.
Molecules
; 18(5): 5517-30, 2013 May 13.
Article
em En
| MEDLINE
| ID: mdl-23669634
ABSTRACT
The synthesis of a newangular analog 11 of cyclozonarone was achieved via Diels-Alder reaction between a sesquiterpene-1,3-diene and 1,4-benzoquinone. The cytotoxic activity of ent-cyclozonarone [(+)-10] and the angular (-)-cyclozonarone analog 11 has been determined in three human cancer cell lines and in normal fibroblasts using the sulforhodamine B assay. The analyzed isomers induce cell death in different cancer cell lines by eliciting nuclear condensation and fragmentation, decreasing mitochondrial membrane permeability and increasing caspase-3 activity, all traits indicating apoptosis, with the effects of (+)-10 being stronger than those of 11 in all cases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
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Núcleo Celular
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Apoptose
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Citotoxinas
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Fibroblastos
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article