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On the road to tolerance--generation and migration of gut regulatory T cells.
Pabst, Oliver; Bernhardt, Günter.
Afiliação
  • Pabst O; Institute of Immunology, Hannover Medical School, Hannover, Germany. Pabst.Oliver@MH-Hannover.de
Eur J Immunol ; 43(6): 1422-5, 2013 Jun.
Article em En | MEDLINE | ID: mdl-23670281
The intestinal immune system potently supports the generation of induced Treg (iTreg) cells. Within intestinal lymphoid compartments iTreg cells receive homing cues, which direct these cells to the gut lamina propria where they expand and locally suppress immune responses. Yet iTreg cells are but one side of a coin, the other side of which comprises natural Treg (nTreg) cells generated in the thymus. nTreg cells, which act in concert with iTreg cells, also acquire a diversified pattern of homing receptors. Thus iTreg and nTreg cells can enter the gut, and draining lymph nodes to cooperatively ensure intestinal homeostasis.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Retorno de Linfócitos / Linfócitos T Reguladores / Intestinos Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Retorno de Linfócitos / Linfócitos T Reguladores / Intestinos Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article