[Malignancies in HIV-infected patients: descriptive study of 129 cases between 1993 and 2010]. / Neoplasias en pacientes con infección por VIH: Estudio descriptivo de 129 casos en el período 1993-2010.
Rev Chilena Infectol
; 30(2): 156-61, 2013 Apr.
Article
em Es
| MEDLINE
| ID: mdl-23677154
ABSTRACT
INTRODUCTION:
The development of malignancies is a problem associated with HIV infection. The incidence and spectrum of malignancies has been modified with the addition of highly active antiretroviral therapy (HAART).AIM:
To describe the clinical and epidemiological characteristics and prognosis of HIV patients who have developed a malignancy.METHODS:
Retrospective observational study was conducted in HIV + patients who developed a malignancy between 1993-2010 in a referral hospital. AIDS-defining malignancies (ADN) and non-AIDS-defining malignancies (NADN) were compared.RESULTS:
125 patients were identified with at least one malignancy. The most frequent malignancies were non-Hodgkin lymphoma (n; 39; 30.2%), Kaposi's sarcoma (n 20; 15.5%), Hodgkin's disease (n 11; 8.8%), lung cancer (n 20; 15.5%) and hepatocellular carcinoma (n 9; 6.9 %). The mean age was 42 ± 11 years, 84% male, 55.8% were coinfected with HBV and or HCV. The risk behaviors were 45.6% intravenous drug users, 16.8% men who have sex with men and 20% heterosexuals). There were 67 (52%) NADN and 62 (48%) ADN; NADN patients had a longer story of HIV infection and longer exposure to HAART, better level of immunodeficiency and better virological control than ADN patients. Four patients developed a second malignancy. Overall survival was 34.7%.CONCLUSIONS:
We found an increased incidence of NADN, appearing in patients with better virological and immunological control than ADN group. Mortality of patients with HIV infection and malignancy is still very high.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Neoplasias
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
Europa
Idioma:
Es
Ano de publicação:
2013
Tipo de documento:
Article