Pulmonary nocardiosis in an immunocompetent patient with COPD: the role of defective innate response.
Heart Lung
; 42(4): 247-50, 2013.
Article
em En
| MEDLINE
| ID: mdl-23680413
ABSTRACT
OBJECTIVES:
Pulmonary nocardiosis is an uncommon opportunistic infection affecting mainly immunocompromised patients. We herein present a case of nocardiosis without profound underlying immunodeficiency.BACKGROUND:
A female, 84-years' old patient with stage IV chronic obstructive pulmonary disease (COPD) is presented. No profound causes of immunodeficiency existed, such as HIV infection, diabetes mellitus, malignancy, alcoholism, chemotherapy or previous corticosteroid intake. The patient recovered after treatment with trimethoprim/sulfamethoxazole for 6 months.RESULTS:
One year after infection resolution, stimulation of the patient's blood monocytes with Nocardia antigens revealed defective production of tumor necrosis factor-alpha, interleukin (IL)-6 and IL-17.CONCLUSION:
We provide preliminary evidence for a link between defective innate immune responses and predisposition for Nocardia infections. Further studies must be conducted in order to fully investigate this mechanism of infection acquisition.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença Pulmonar Obstrutiva Crônica
/
Imunidade Inata
/
Nocardiose
Tipo de estudo:
Diagnostic_studies
Limite:
Aged80
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article